This course introduces the knowledge in digital medicine, technologies, and the associated big data and analysis to students with non-biology background, focusing on the public health issues with the global insights. Digital medicine is the convergence of digital technologies (including genomic technologies) with medicine, living, and society to enhance the efficiency of medicine delivery and make medicines more personalized and precise. This course covers high-throughput (HT) genotyping, HT phenotyping, artificial intelligence, big data analysis, public database, proteomics and other omics. The goal of this course is to develop students’ understanding of digital medicine and required analytical skills for the exciting possibilities towards creating a new paradigm of precision medicine.