Public health emergencies take a terrible toll, both on human life and global economy. This course introduces strategies for managing epidemics, using COVID-19, SARS, AIDS (HIV), pandemic influenza, Ebola virus disease, yellow fever, Zika, cholera, and plague as examples. It covers the pathophysiology of different diseases, the principles of testing, tracing and isolation (TTI), the expert guidance from World Health Organization (WHO) for effective epidemic responses, and lessons learned from success and failure in managing epidemics.